The day will involve four sessions comprised of 15 or 5 minute student talks, keynote talks from Nicole Soranzo and Brian Charlesworth and two poster sessions. It will conclude with an informal dinner at a nearby restaurant.

The topics include mathematical, statistical, bioinformatic and computational approaches to population, evolutionary, quantitative and disease genetics and to general genomics. The specific sessions are driven entirely by the submitted abstracts.
Registration and coffee  (09:00 – 09:30)
Session I: Genetic and Epigenetic Variation (09:30 – 10:30)
Chair: Sarah Morgan








Erik Garrison (Wellcome Trust Sanger Institute, Hinxton, Cambridge UK):
Resequencing against a human whole genome variation graph’
Patrick K. Albers (Wellcome Trust Centre for Human Genetics, University of Oxford, UK):
‘Shared haplotype estimation using rare variants to identify tracts of common ancestry’
Victoria Hore (Department of Statistics, University of Oxford, UK):
‘Sparse Bayesian latent factor decompositions for identifying trans-eQTLs’
Charles E. Breeze (UCL Cancer Institute, University College London, London, UK):
‘eFORGE: a tool for identifying tissue-specific signal in epigenetic data’
Vagheesh Narasimhan (Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK):
Human Knockout Project – Impact and architecture of naturally-occurring gene knockouts in parentally-related fit adult humans
Sarah Marzi ( Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK):
‘Methylomic variation in adolescents exposed to severe early-life adversity.’

Poster session I and coffee break  (10:30 – 11:15)
Keynote talk: Prof Brian Charlesworth: “Recombination, genome organisation and molecular evolution in Drosophila” (11:15 – 12:00)
Session II: Population Genomics and Adaptation (12:00 – 13:00)
Chair: Moises Exposito-Alonso






Marie Lopez (Institut Pasteur, HEG, CNRS URA3012, Paris, France):
Assessing the impact of demography on selection and adaptation in humans
Hilary C. Martin (Wellcome Trust Centre for Human Genetics, University of Oxford, UK):
Insights into sex chromosome evolution from whole-genome sequencing of platypus’
Tom R. Booker (Institute of Evolutionary Biology, University of Edinburgh, UK):
Simulating genome evolution in the house mouse: understanding the contribution of Hill-Robertson interference to patterns of genetic diversity
Ignacio Vázquez-García (Wellcome Trust Sanger Institute, Dep. of Applied Mathematics and Theoretical Physics, University of Cambridge, UK):
Transient dynamics of selection and adaptation in heterogeneous populations
Thomas C. Nelson (Institute of Ecology and Evolution, Eugene, OR, USA):
Standing genetic variation drives rapid adaptation of the threespine stickleback

Lunch break  (13:00 – 14:00)
Keynote talk: Dr. Nicole Soranzo: “Next generation association studies of complex traits”  (14:00 – 14:45)
Session III: Gene Expression and Regulation (14.45 – 15:45)
Chair: Kaur Alasoo







Emma Pierson (Department of Statistics, Oxford, United Kingdom – Wellcome Trust Centre for Human Genetics):
New Statistical Methods for scRNA-seq Data
Mitra Barzine (European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK):
‘Integration of independent human RNA-seq datasets – a feasibility study
Davis McCarthy (Wellcome Trust Centre for Human Genetics, Oxford, UK – Department of Statistics, University of Oxford, UK):
Identifying quiescent stem cells from single-cell RNA-seq data with ‘scater’
Christof Angermueller (European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK):
Machine learning for the combined analysis of scBS-Seq and scRNA-Seq data
Kieran Campbell(MRC Functional Genomics Unit, University of Oxford UK):
High-resolution pseudotemporal ordering of single-cell gene expression profiles’
Malcolm Perry (MRC Clinical Sciences Centre – Imperial College, UK):
Inferring long-range regulation from chromatin data

Poster session III and coffee break  (15:45 – 16:30)
Session IV: Disease Genomics and Complex Phenotypes (16:30 – 17:30)
Chair: Hannah Meyer







D. Leland Taylor (National Human Genome Research Institute, Bethesda, MD, USA – EMBL‑European Bioinformatics Institute, Hinxton, UK):
The genetic architecture of metabolic response in skeletal muscle expression
Nicola Roberts (Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom):
Deciphering mutational signatures in cancer with the hierarchical Dirichlet process
Jonas Zierer(Dep. for Twin Research KCL, UK, Ins. of Bioinformatics & Systems Biology Helmholtz Zentrum München, Germany):
Integration of Multi-Omics Data in Ageing Research
Annique Claringbould(Imperial College London, UK):
Multi-phenotype analysis of cardiometabolic traits through usage of multivariate analytical methods
James Liley(Juvenile Diabetes Research Foundation, Dep. of Medical Genetics, University of Cambridge, UK):
Approaches to disease heterogeneity in genomic analysis
Siobhan Connolly (Trinity College Dublin, Ireland):
Investigation of Assortative Mating in Autism Spectrum Disorders

Post-conference drinks (Prince Arthur Pub)  (17:30 – late)


Poster List
Poster Session I: (10:30 – 11:15 and 13h-13h30)

Mark Hill (University College London, UK – University of Sussex, UK)

‘Identification and characterisation of sexually antagonistic loci in Drosophila melanogaster’

Kevin Rue-Albrecht (University College Dublin, Ireland)

‘GOexpress: A R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised clustering of gene expression data’

John Lees (Wellcome Trust Sanger Institute, UK)

‘Using hierarchical models to determine bacterial virulence from short read sequence data’

Oliver Pain (Birkbeck, University of London, UK – London School of Hygiene and Tropical Medicine, UK – King’s College London, UK.)

‘Genome-wide Association Study of Specific Psychotic Experiences in Adolescence’

Rosina Savisaar (University of Bath, UK)

‘No evidence for avoidance of exonic splice enhancers in intronless genes’

Katrina de Lange (Wellcome Trust Sanger Institute, UK)

‘Rare variation association testing in low coverage whole genome sequences, when confounded by read depth’

Sebastian Steinhauser (IPMB, Heidelberg University Germany – German Cancer Research Institute DKFZ Heidelberg)

‘A comprehensive comparison of tools for differential ChIP-seq analysis’

Sarah Earle (Nuffield Department of Medicine, Oxford University, UK)

‘Test-driving genome wide association studies in Staphylococcus aureus’

Robyn E Wootton (University of Warwick, UK – University of Bristol, UK)

‘A Genetic Investigation of Wellbeing’

Yunfeng Ruan (Shanghai Jiao Tong University, China – Shanghai Pulmonary Hospital, China)

‘Multivariate gene association study of advanced NSCLC patients’ response to targeted drugs’

Daniel P. Temko (University College London, UK)

‘Modelling the growth of ultramutator cancers, and explaining their good prognosis’

Katie Burnham (Wellcome Trust Centre for Human Genetics, University of Oxford, UK – William Harvey Research Institute, Barts and The London School of Medicine, UK – Imperial College, London, UK – John Radcliffe Hospital, Oxford, UK)

‘Distinct gene expression signatures revealed in severe sepsis patients with differing infectious aetiology’

Poster Session II: (13h30-14h and 15:45 – 16:30)

Mary Fortune (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, UK)

‘A Framework for Inferring Genetic Architecture from GWAS Summary Statistics, Using Approximate Bayesian Computation’

Anders Bergström (Wellcome Trust Sanger Institute, UK – Stanford University, CA, USA – Harvard Medical School, MA, USA)

‘High-coverage sequencing of 952 genomes from 52 worldwide human populations’

Alice Stanley (Wellcome Trust Sanger Institute, UK- European Bioinformatics Institute, UK – University of Cambridge, UK)

‘Investigating the role of cohesin-non-CTCF sites in cell-type specific gene regulation and genetic variation’

Filip Ruzicka (University College London, UK)

‘Beyond Drosophila Melanogaster: A comparative approach to unravelling the genetic basis of sexual antagonism’

Daniel Greene (University of Cambridge – MRC Biostatistics Unit – Wellcome Trust Sanger Institute, UK)

‘Bayesian HPO Similarity Regression: A Method For Associating Genotype With Complex Disorders’

Nicholas Cooper (University of Cambridge, Diabetes and Inflammation Laboratory, UK)

‘Expanding the search for type 1 diabetes susceptibility regions and candidate causal SNPs using ImmunoChip and genome-wide imputation’

Elena Loizidou (Imperial College London)

‘Population-haplotype models for mapping structural variation using whole genome sequencing and for jointly imputing / genotyping these in very large GWAS samples’

Jacek Marzec (Queen Mary University of London, UK)

‘Transcriptomics integrative analysis of microarray and next-generation sequencing data’

Joseph G.W. McCarter (Centre for Chromosome Biology, National University of Ireland, Galway, Ireland)

‘Quantitative analysis of centromere domains using naturally occurring system of satellite-free centromeres in Equus asinus’

Christina Wesse (University of Osnabrück)

‘Evolutionary adaptation of Shepherd’s Purse in recently colonized areas’

Craig Glastonbury (King’s College London, UK- University of Geneva Medical School, Switzerland – Wellcome Trust Sanger Institute, UK )

‘Utilizing gene expression to uncover genotype-dependent effects of BMI in multiple tissues.’

Agathe Jouet (The Sainsbury Laboratory, Norwich, UK – The University of East Anglia, Norwich, UK – University Claude Bernard Lyon, France – University of Trento, Italy – The Genome Analysis Centre, Norwich, UK)

‘The adaptive evolution of Albugo candida’